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Title   한국산 영지버섯이 벤조피렌으로 유발된 마우스 폐선종에 미치는 영향 ( Effects of Ganoderma lucidum on Mouse Pulmonary Adenoma Induced by Benzo(a)pyrene
Publicationinfo   1993 Jan; 025(04): 531-539.
Key_word   Ovarian cancer, Combinstion chemotherapy, VP-16, Cisplatin
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Abstract   Thirty five patients with the advanced epithelial ovarian cancer were treated with VP-16 plus cisplatin(VPP). The treatment consists of VP-16(100mg/m(2), IV, day 1~3) and cisplatin (20 mg/m, IV, day 1~5) every 3 weeks; Five patients were inevaluable for response because they were lost to follow up after the first course of treatment. Of the 30 evaluable patients, 21 (70k) patients had been previously treated with other chemotherapy regimen. Ten patients achieved complete responses(33%) and five patients achieved partial responses(17%), giving an overall response rate of 50%. The median disease-free interval for the complete responders and the median response duration for all responders were 10.5 months(the range; 1~27+) and 16 months(the range: 3~32+), respectively. Overall survival time ranged from 2 months to 45 months with a median value of 25 months. The main hematologic toxicities were the: leukopenia(39%) and anemia(48%), and non-hematologic side effeets included. nausea,. vomiting, alopecia, and pesipheral neuropathy. These toxicities were observed commonly, but most of those were of mild degree and easily manageable. In conclusion, VPP combination chemotherapy is an effective treatment reaimen for the advanced epithelial ovarian cancer.
저 자   윤택구(Taik Ku Yun),이윤실(Yun Sil Lee)